Cancer cell apoptosis, differentiation and necrosis

In contrast to cell death (necrosis) caused by toxic chemotherapy drugs, inducing apoptosis or differentiating cancer cells into normal cells is an excellent way to cure cancer.

When cancer cells are threatened by toxic chemotherapy drugs, they immediately activate defense mechanisms to resist the attack by changing the structure of their DNA. In the process, they may even develop broad-spectrum drug resistance.

Studies have shown that if the attack targets the cell membrane or DNA, causing its structure to be destroyed, closely followed by some powerful healing agents that can initiate apoptosis (for cells that are not salvageable) or differentiate into normal cells, even solid tumors will disappear.

Without healing agents, cancer cells will transform into more primitive and aggressive cancer types, but in the presence of healing agents and nutrients needed for cell repair, cancer cell apoptosis and differentiation can be induced.

In the presence of repair agents, damaged cancer cells will follow two pathways: apoptosis (programmed cell death) and differentiation into normal cells. Differentiation is basically a healing process, and in order to heal, damaged cells should receive various nutrients needed to build strong and normal cells. Nutritional therapy is necessary complementary treatment.

No symptoms were observed during the process of apoptosis, and similarly during the differentiation of cancer cells into normal cells, few, if any, toxins were produced in the body, thus protecting the liver. Additionally, there is no swelling or inflammation caused by differentiating cancer cells into normal cells.

Additionally, treatments that differentiate cancer cells into normal cells could theoretically cure cancer within 24 hours, although the complete switch in metabolism takes 2 or 3 weeks to complete within the cells

When a cell undergoes apoptosis, the entire cell, including the nucleus, splits into many fragments, known as apoptotic bodies. The entire process from cell apoptosis to the formation of apoptotic bodies is completed within a few minutes. At the same time, the apoptotic cell's genetic material, known as DNA, breaks down into a characteristic pattern of fragments of different sizes. During cell division, cells continue to produce proteins and adenosine triphosphate (ATP), molecules required for most of the cell's energy-consuming metabolic processes and critical to cell function. Therefore, each apoptotic body surrounded by a cell membrane contains intact, functional cellular components (i.e., organelles).

In contrast, necrotic cell death is characterized by the loss of metabolic function and cell membrane integrity. As a result, cells that undergo necrosis stop producing protein and ATP. Structurally, the cell's organelles swell and become nonfunctional during the initial stages of necrosis. In addition, the cell membrane forms bubble-like projections (i.e., blebs). These blebs, which contain no organelles, fuse and grow in size. Eventually, the cell membrane ruptures, causing the release of cellular components into surrounding tissue. This process of cell dissolution is called cytolysis. The released cellular contents subsequently cause an inflammatory response in affected tissues, such as the liver. This response is mediated by three components:

(1) Certain cells of the immune system are attracted to the liver;

(2) small molecules called cytokines involved in cell communication; and

(3) Active oxygen (i.e. oxygen free radicals). The subsequent inflammatory response is generally considered a component of necrosis and can further damage liver tissue.

The necrotic process of cell death is always damaging or harmful. It is said that if left untreated, necrosis is very dangerous and can be fatal.

In addition to cancer cells, chemotherapy and radiotherapy may also cause the necrotic death of normal cells, leading to a more widespread inflammatory state.